Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NAT1 | P18440 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635630 | 0.91 | AR (0.40) | ARMAPTGAAPOLBMEN1 | |
| SCHEMBL8630518 | 0.89 | AR (0.43) | ARPTGS1PTGS2MAPTKDM1A | |
| SCHEMBL8635051 | 0.88 | SMN1; SMN2 (0.42) | ARPTGS1PTGS2MAPTKDM1A | |
| SCHEMBL8631648 | 0.87 | AR (0.41) | ARPTGS1PTGS2MAPTKDM1A | |
| SCHEMBL8633218 | 0.85 | EDNRB (0.42) | MAPTKDM1AEDNRBEDNRAGAA | |
| SCHEMBL8632683 | 0.85 | MEN1 (0.40) | ARPTGS1PTGS2MAPTKDM1A | |
| SCHEMBL8629870 | 0.83 | NPC1 (0.39) | PTGS1PTGS2MAPTKDM1AGHSR | |
| SCHEMBL8628706 | 0.81 | MAPT (0.44) | MAPTKDM1AEDNRBEDNRAGAA | |
| SCHEMBL8629951 | 0.81 | MAPT (0.43) | MAPTKDM1AEDNRBEDNRAGAA | |
| SCHEMBL8631394 | 0.81 | AR (0.43) | ARPTGS2MAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |