Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | NAT1 | P18440 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629075 | 0.89 | MAPT (0.42) | MAPTPOLBGAAALDH1A1MEN1 | |
| SCHEMBL8631602 | 0.89 | CDC25A (0.43) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8629350 | 0.89 | SMN1; SMN2 (0.46) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8628706 | 0.87 | MAPT (0.44) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8633160 | 0.87 | MEN1 (0.43) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8628554 | 0.87 | PRMT1 (0.41) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8633218 | 0.85 | EDNRB (0.42) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8635404 | 0.85 | MAPT (0.41) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8631576 | 0.85 | MAPT (0.41) | MAPTKDM1APOLBGAAEDNRB | |
| SCHEMBL8632284 | 0.81 | AR (0.40) | MAPTKDM1APOLBGAAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |