Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630539 | 0.92 | PTGS2 (0.46) | SMN1; SMN2MAPTMEN1KMT2AKDM1A | |
| SCHEMBL8629346 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8631859 | 0.90 | KDM1A (0.41) | SMN1; SMN2MAPTMEN1KMT2AKDM1A | |
| SCHEMBL8631151 | 0.87 | MEN1 (0.41) | MAPTMEN1KMT2AKDM1APTGDR2 | |
| SCHEMBL8630962 | 0.87 | PTGS2 (0.44) | MAPTMEN1KMT2AKDM1APTGDR2 | |
| SCHEMBL8632875 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTMEN1KMT2AEDNRB | |
| SCHEMBL8631027 | 0.83 | PTGS2 (0.42) | SMN1; SMN2MAPTMEN1KMT2APTGDR2 | |
| SCHEMBL8632313 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTMEN1KMT2AKDM1A | |
| SCHEMBL8631604 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTMEN1KMT2AKDM1A | |
| SCHEMBL8630021 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |