Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488735 | 0.93 | SMN1; SMN2 (0.46) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8630021 | 0.93 | SMN1; SMN2 (0.49) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8629118 | 0.93 | PTGS2 (0.57) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8630539 | 0.92 | PTGS2 (0.46) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8633058 | 0.90 | PTGS2 (0.44) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8631387 | 0.90 | PTGS2 (0.44) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8634609 | 0.90 | KMT2A (0.45) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8630170 | 0.87 | CDC7 (0.43) | SMN1; SMN2PTGS2MAPTKMT2AEDNRB | |
| SCHEMBL8630200 | 0.86 | MAPT (0.50) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 | |
| SCHEMBL8629750 | 0.86 | MAPT (0.46) | SMN1; SMN2PTGS2PTGS1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |