SCHEMBL8630962

SCHEMBL8630962

O=S(=O)(Nc1nn(CCc2ccccc2)c(C(F)(F)C(F)(F)F)c1-c1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.44
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PRMT1 Q99873 1/20 0.40
KDM1A O60341 2/20 0.39
EDNRB P24530 2/20 0.38
EDNRA P25101 2/20 0.38
TP53 P04637 2/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
MYLK Q15746 1/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.36
S1PR1 P21453 1/20 0.36
THRB P10828 1/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
ALOX12 P18054 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8631859 0.91 KDM1A (0.41) ATML3MBTL1PRMT1KDM1AEDNRB
SCHEMBL8632826 0.90 PTGS2 (0.46) PTGS2TP53ALDH1A1GAATHRB
SCHEMBL8628734 0.87 SMN1; SMN2 (0.44) PTGS2KDM1AEDNRBEDNRATP53
SCHEMBL8631151 0.85 MEN1 (0.41) PTGS2KDM1AEDNRBEDNRAALDH1A1
SCHEMBL8627773 0.83 PRMT1 (0.42) PTGS2ATML3MBTL1PRMT1KDM1A
SCHEMBL8632283 0.83 PTGS2 (0.63) PTGS2TP53THRBMAPTMEN1
SCHEMBL8629982 0.83 EDNRB (0.43) PTGS2ATML3MBTL1KDM1AEDNRB
SCHEMBL8630563 0.83 PRMT1 (0.43) PTGS2PRMT1KDM1ATP53ALDH1A1
SCHEMBL8631027 0.82 PTGS2 (0.42) PTGS2ATML3MBTL1ALDH1A1PTGDR2
SCHEMBL8631050 0.82 PTGS2 (0.42) PTGS2TP53MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756530-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS G. D. SEARLE & CO. (US) 1998-05-26 US disclosed