Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631745 | 0.93 | PTGS2 (0.41) | MAPTMEN1KMT2ASMN1; SMN2PPARA | |
| SCHEMBL8630479 | 0.91 | CCR4 (0.41) | PPARAHTR6PI4KBPTGS2PTGS1 | |
| SCHEMBL8632815 | 0.90 | PTGS2 (0.38) | PPARAHTR6PI4KBPTGS2PTGS1 | |
| SCHEMBL8631050 | 0.90 | PTGS2 (0.42) | MAPTPPARAHTR6PI4KBPTGS2 | |
| SCHEMBL8630468 | 0.86 | SMN1; SMN2 (0.50) | MAPTMEN1KMT2ASMN1; SMN2HTR6 | |
| SCHEMBL8630562 | 0.84 | CCR4 (0.42) | PPARAPI4KBPTGS2PTGS1 | |
| SCHEMBL8631448 | 0.84 | SMN1; SMN2 (0.40) | MAPTMEN1KMT2ASMN1; SMN2HTR6 | |
| SCHEMBL8629955 | 0.84 | MAPT (0.46) | MAPTMEN1KMT2ASMN1; SMN2PPARA | |
| SCHEMBL8634271 | 0.84 | PTGS2 (0.41) | MAPTMEN1KMT2ASMN1; SMN2HTR6 | |
| SCHEMBL8629346 | 0.83 | SMN1; SMN2 (0.47) | MAPTMEN1KMT2ASMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |