SCHEMBL8629196

SCHEMBL8629196

Nc1c(C(=O)O)cccc1C(=O)CCn1cnc2c(=O)[nH]cnc21

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 16/20 0.50
PNP P00491 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7684224 0.80 HPRT1 (0.49) HPRT1PNP
SCHEMBL7374581 0.78 HPRT1 (0.64) HPRT1PNP
SCHEMBL3060815 0.77 HPRT1 (0.63) HPRT1PNP
SCHEMBL7397072 0.74 HPRT1 (0.59) HPRT1PNP
SCHEMBL3126819 0.72 ADORA2A (0.60) HPRT1PNP
SCHEMBL7684892 0.72 HPRT1 (0.67) HPRT1PNP
Leteprinim SCHEMBL358491 0.72 HPRT1 (0.50) HPRT1PNP
SCHEMBL11258920 0.71 HPRT1 (0.69) HPRT1PNP
Leteprinim SCHEMBL6931317 0.71 HPRT1 (0.49) HPRT1PNP
Leteprinim SCHEMBL6935182 0.71 HPRT1 (0.49) HPRT1PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5801184-A Carbon monoxide dependent guanylyl cyclase modifiers and methods of use SPECTRUM PHARMACEUTICALS, INC. 1998-09-01 US disclosed