Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673984 | 0.81 | PTGS2 (0.68) | PTGS2PTGS1KIF11 | |
| SCHEMBL1228636 | 0.80 | MAPKAPK2 (0.45) | MELKMAPKAPK2 | |
| SCHEMBL29266901 | 0.79 | ABL1 (0.51) | MELKMAPKAPK2 | |
| SCHEMBL8631359 | 0.79 | MELK (0.63) | MELKPTGS2PTGS1MAPKAPK2KIF11 | |
| SCHEMBL182400 | 0.79 | MAPKAPK2 (0.56) | MELKMAPKAPK2 | |
| SCHEMBL8633662 | 0.79 | MELK (0.76) | MELKPTGS2PTGS1 | |
| SCHEMBL8630577 | 0.78 | MELK (1.00) | MELKPTGS2PTGS1MAPKAPK2 | |
| SCHEMBL514383 | 0.77 | PTGS2 (0.65) | PTGS2PTGS1KIF11 | |
| SCHEMBL23928566 | 0.76 | PTGS2 (0.69) | PTGS2 | |
| SCHEMBL6290646 | 0.76 | PTGS2 (0.64) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |