Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630160 | 0.79 | MELK (0.65) | MELKPTGS2PTGS1KIF11MAPKAPK2 | |
| SCHEMBL18850964 | 0.79 | CA12 (0.70) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL8628053 | 0.78 | KMT2A (0.45) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL8633662 | 0.75 | MELK (0.76) | MELKPTGS2PTGS1 | |
| SCHEMBL8630577 | 0.74 | MELK (1.00) | MELKPTGS2PTGS1MAPKAPK2MAP4K4 | |
| SCHEMBL28715217 | 0.72 | RORC (0.63) | — | |
| SCHEMBL27721532 | 0.70 | ALKBH2 (0.64) | MELKCA12CA9PTGS2PTGS1 | |
| SCHEMBL7772921 | 0.70 | CA12 (0.47) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL8629890 | 0.69 | MELK (0.73) | MELKCA12CA1CA2CA9 | |
| SCHEMBL7777513 | 0.68 | CA12 (0.45) | CA12CA1CA2CA9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |