SCHEMBL8630198

SCHEMBL8630198

CSc1cc(C(F)(F)F)ccc1C(N)=CC(=O)C1CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.38
CCR2 P41597 8/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
HSD17B10 Q99714 2/20 0.37
CFTR P13569 1/20 0.36
GAA P10253 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
CES2 O00748 1/20 0.35
CCR3 P51677 1/20 0.35
CYP2C19 P33261 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
USP2 O75604 1/20 0.33
NR4A1 P22736 1/20 0.33
NR4A2 P43354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8630195 1.00 SLC6A9 (0.38) SLC6A9CCR2KDM4EALDH1A1HPGD
SCHEMBL8629066 0.81 ADRA1D (0.34) KDM4EALDH1A1HPGDGAATDP1
SCHEMBL2325301 0.77 KDM4E (0.47) SLC6A9KDM4EALDH1A1HPGDHSD17B10
SCHEMBL8886678 0.76 GAA (0.40) SLC6A9CCR2KDM4EALDH1A1HPGD
SCHEMBL29391001 0.75 SLC6A9 (0.41) SLC6A9CCR2KDM4EALDH1A1HPGD
SCHEMBL6751338 0.75 SLC6A9 (0.41) SLC6A9CCR2KDM4EALDH1A1HPGD
SCHEMBL28017759 0.74 SLC6A9 (0.39) SLC6A9CCR2KDM4EALDH1A1HPGD
SCHEMBL28095379 0.74 CES2 (0.49) SLC6A9KDM4EALDH1A1HPGDHSD17B10
SCHEMBL8492736 0.74 PTGDR2 (0.36) SLC6A9CCR2GAAUSP2
SCHEMBL8763685 0.74 PTGDR2 (0.36) SLC6A9CCR2GAAUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705243-B1 BETA-AMINOVINYL KETONES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR PREPARING BETA DIKETONES RHONE POULENC AGROCHIMIE (FR) 1998-06-24 EP disclosed
US-5684206-A CONDENSING METHYL ORGANO KETONE WITH A BENZONITRILE IN PRESENCE OF STRONG BASE RHONE-POULENC ARGOCHIMIE (FR) 1997-11-04 US disclosed
EP-0705243-A1 BETA-AMINOVINYL KETONES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR PREPARING BETA DIKETONES RHONE-POULENC AGROCHIMIE (FR) 1996-04-10 EP disclosed
WO-1995000476-A1 BETA-AMINOVINYL KETONES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR PREPARING BETA DIKETONES RHONE POULENC AGROCHIMIE (FR) 1995-01-05 WO disclosed