Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2436058 | 0.80 | KDM5A (0.35) | KDM5AKDM4CKMT2AMAPTALDH1A1 | |
| SCHEMBL321702 | 0.77 | LMNA (0.49) | LMNANPC1KDM5AKDM4CKMT2A | |
| SCHEMBL1892244 | 0.75 | LMNA (0.48) | LMNANPC1KDM5AKDM4CKMT2A | |
| SCHEMBL112586 | 0.75 | LMNA (0.44) | LMNANPC1KDM5AKDM4CKMT2A | |
| SCHEMBL10425052 | 0.75 | LMNA (0.44) | LMNANPC1KDM5AKDM4CKMT2A | |
| SCHEMBL8634114 | 0.75 | LMNA (0.44) | LMNANPC1KDM5AKDM4CKMT2A | |
| SCHEMBL6831429 | 0.74 | LMNA (0.50) | LMNANPC1RAB9AKDM5AKDM4C | |
| SCHEMBL10425028 | 0.73 | LMNA (0.43) | LMNANPC1RAB9AKDM5AKDM4C | |
| SCHEMBL14961223 | 0.73 | NPC1 (0.49) | LMNANPC1RAB9AKDM5AKDM4C | |
| SCHEMBL1252596 | 0.73 | LMNA (0.49) | LMNANPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712281-A | Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines | FMC CORPORATION (US) | 1998-01-27 | — | — | US | disclosed |
| US-5536725-A | Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines | FMC CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |