Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 6/20 | 0.55 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630648 | 0.81 | FDPS (0.63) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Zinc Ion SCHEMBL9954299 | 0.79 | FDPS (0.50) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Lithium Ion SCHEMBL8632583 | 0.78 | MMP8 (0.49) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Lithium Ion SCHEMBL986768 | 0.77 | NAPRT (0.69) | CYP1A2CYP3A4CYP2C9NAPRTRECQL | |
| SCHEMBL8633568 | 0.75 | FDPS (0.50) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| SCHEMBL3726238 | 0.74 | CYP3A4 (0.47) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| SCHEMBL14036231 | 0.73 | CYP1A2 (0.61) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| SCHEMBL27624565 | 0.73 | NAPRT (0.69) | CYP1A2CYP3A4CYP2C9NAPRTRECQL | |
| SCHEMBL15516269 | 0.73 | CYP1A2 (0.61) | FDPSBTN3A1PDE3ACYP1A2CYP3A4 | |
| Potassium Ion SCHEMBL17653885 | 0.73 | NAPRT (0.69) | CYP1A2CYP3A4CYP2C9NAPRTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773465-A | Tartronic acids, their acetalic ethers and o-esters | DOMPE FARMACEUTICI S.P.A. (IT) | 1998-06-30 | — | — | US | disclosed |
| US-5656656-A | Tartronic acids, their acetalic ethers and O-esters | DOMPE FARMACEUTICI S.P.A. (IT) | 1997-08-12 | — | — | US | disclosed |
| EP-0667850-B1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE FARMACEUTICI SPA (IT) | 1997-05-28 | — | — | EP | disclosed |
| EP-0667850-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS. | DOMPE FARMACEUTICI SPA (IT) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994010127-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE' FARMACEUTICI S.P.A. (IT) | 1994-05-11 | — | — | WO | disclosed |