Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628952 | 0.86 | PTGS2 (0.41) | PTGES2PTGS1PTGS2F10ALOX5AP | |
| SCHEMBL8627977 | 0.86 | PTGS2 (0.50) | PTGES2PTGS1PTGS2F10CA12 | |
| SCHEMBL8631662 | 0.85 | F10 (0.42) | PTGES2F10MAOBIDO1CA12 | |
| SCHEMBL8631176 | 0.84 | PTGS2 (0.46) | PTGES2PTGS1PTGS2CA12CA1 | |
| SCHEMBL7780688 | 0.83 | MAOA (0.52) | PTGES2PTGS1PTGS2MAOBCA12 | |
| SCHEMBL8634777 | 0.83 | CA1 (0.40) | PTGES2PTGS1PTGS2F10CA12 | |
| SCHEMBL8632289 | 0.83 | AKR1B1 (0.40) | PTGS2F10CA12CA1CA2 | |
| SCHEMBL8629390 | 0.82 | PTGES2 (0.43) | PTGES2PTGS2F10NPSR1CA12 | |
| SCHEMBL8630031 | 0.82 | PTGS2 (0.41) | PTGS1PTGS2F10ALOX5APFEN1 | |
| SCHEMBL8632961 | 0.82 | F10 (0.40) | F10ALOX5APFEN1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |