Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 2/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758930 | 0.93 | CYP2A6 (0.42) | KMT2ATSHRIDH2PIK3CALRRK2 | |
| SCHEMBL8629976 | 0.89 | L3MBTL1 (0.51) | KMT2AL3MBTL1LRRK2ALDH1A1MEN1 | |
| SCHEMBL8628831 | 0.87 | LRRK2 (0.50) | KMT2AIDH2L3MBTL1PIK3CALRRK2 | |
| SCHEMBL8631355 | 0.82 | L3MBTL1 (0.44) | KMT2AL3MBTL1LRRK2HDAC4MEN1 | |
| SCHEMBL8634943 | 0.82 | MAP2K4 (0.44) | KMT2AIDH2L3MBTL1PIK3CALRRK2 | |
| SCHEMBL8632682 | 0.81 | KDM1A (0.46) | KMT2AL3MBTL1LRRK2ALDH1A1HDAC4 | |
| SCHEMBL8629853 | 0.81 | MEN1 (0.45) | KMT2AL3MBTL1LRRK2USP2USP8 | |
| SCHEMBL8633591 | 0.81 | L3MBTL1 (0.43) | KMT2ATSHRL3MBTL1LRRK2USP2 | |
| SCHEMBL8635392 | 0.81 | L3MBTL1 (0.49) | KMT2ATSHRL3MBTL1LRRK2ALDH1A1 | |
| SCHEMBL8630886 | 0.81 | MCL1 (0.45) | KMT2ATSHRL3MBTL1LRRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |