Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GYS1 | P13807 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629976 | 0.92 | L3MBTL1 (0.51) | L3MBTL1KDM4ERXFP1GYS1MAPT | |
| SCHEMBL8633591 | 0.89 | L3MBTL1 (0.43) | L3MBTL1KDM4ERXFP1MAPTMEN1 | |
| SCHEMBL8635392 | 0.89 | L3MBTL1 (0.49) | L3MBTL1KDM4EMAPTPOLBKMT2A | |
| SCHEMBL8632682 | 0.89 | KDM1A (0.46) | L3MBTL1KDM4ERXFP1GYS1MAPT | |
| SCHEMBL8629853 | 0.89 | MEN1 (0.45) | L3MBTL1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL8628831 | 0.88 | LRRK2 (0.50) | L3MBTL1KDM4ERXFP1GYS1MAPT | |
| SCHEMBL8634943 | 0.87 | MAP2K4 (0.44) | L3MBTL1MAP2K4MAPK14MEN1KMT2A | |
| SCHEMBL8631696 | 0.86 | SLC40A1 (0.42) | L3MBTL1MAPTLRRK2EDNRBEDNRA | |
| SCHEMBL8627990 | 0.86 | HPGD (0.41) | L3MBTL1MAPTMEN1POLBKMT2A | |
| SCHEMBL8633701 | 0.86 | KMT2A (0.48) | L3MBTL1KDM4EMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |