Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632875 | 0.90 | SMN1; SMN2 (0.50) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8630021 | 0.89 | SMN1; SMN2 (0.49) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8629118 | 0.89 | PTGS2 (0.57) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8630539 | 0.88 | PTGS2 (0.46) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8488735 | 0.86 | SMN1; SMN2 (0.46) | PTGS2SMN1; SMN2PTGS1HSD11B1MEN1 | |
| SCHEMBL8634609 | 0.86 | KMT2A (0.45) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8633058 | 0.86 | PTGS2 (0.44) | PTGS2SMN1; SMN2PTGS1MEN1MAPT | |
| SCHEMBL8628839 | 0.83 | EDNRB (0.41) | PTGS2SMN1; SMN2HSD11B1MEN1MAPT | |
| SCHEMBL8632202 | 0.83 | MAPT (0.39) | PTGS2SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL8629750 | 0.82 | MAPT (0.46) | PTGS2SMN1; SMN2PTGS1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |