Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632875 | 0.90 | SMN1; SMN2 (0.50) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8629382 | 0.90 | ALDH1A1 (0.41) | PTGS2SMN1; SMN2ALDH1A1TSHRPOLB | |
| SCHEMBL8629118 | 0.89 | PTGS2 (0.57) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8630021 | 0.89 | SMN1; SMN2 (0.49) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8634392 | 0.88 | PTGS2 (0.48) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8629104 | 0.88 | ALDH1A1 (0.36) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8629114 | 0.88 | ALDH1A1 (0.36) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8630539 | 0.88 | PTGS2 (0.46) | PTGS2SMN1; SMN2PTGS1ALDH1A1TSHR | |
| SCHEMBL8632637 | 0.88 | EDNRB (0.40) | PTGS2SMN1; SMN2ALDH1A1TSHRPOLB | |
| SCHEMBL8632219 | 0.88 | ALDH1A1 (0.39) | PTGS2SMN1; SMN2ALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |