Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630171 | 0.90 | PTGS2 (0.45) | F10PTGS2PTGS1F2 | |
| SCHEMBL8634613 | 0.89 | PTGS2 (0.55) | F10PTGS2PTGS1F2SCN9A | |
| SCHEMBL8629933 | 0.89 | PTGS2 (0.46) | F10CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8635534 | 0.88 | PTGS2 (0.53) | F10PTGS2PTGS1F2 | |
| SCHEMBL8629984 | 0.88 | PTGS2 (0.44) | F10CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8629384 | 0.87 | PTGS2 (0.44) | F10PTGS2PTGS1F2 | |
| SCHEMBL8630564 | 0.87 | PTGS2 (0.45) | F10PTGS2PTGS1F2 | |
| SCHEMBL8630046 | 0.87 | PTGS2 (0.42) | F10CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7773345 | 0.87 | PTGS2 (0.59) | F10CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8631395 | 0.86 | F10 (0.47) | F10PTGS2PTGS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |