Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630171 | 0.94 | PTGS2 (0.45) | PTGS2PTGS1IDO1TDO2ALDH1A1 | |
| SCHEMBL8629984 | 0.92 | PTGS2 (0.44) | PTGS2PTGS1ALDH1A1KMT2AENPP1 | |
| SCHEMBL8629933 | 0.91 | PTGS2 (0.46) | PTGS2PTGS1IDO1TDO2ALDH1A1 | |
| SCHEMBL8632288 | 0.90 | PTGS2 (0.67) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8629384 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1KMT2AENPP1F10 | |
| SCHEMBL8631441 | 0.88 | F10 (0.49) | PTGS2PTGS1F10F2 | |
| SCHEMBL8629123 | 0.88 | PTGS2 (0.70) | PTGS2PTGS1F10 | |
| SCHEMBL8630527 | 0.87 | PTGS2 (0.42) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL7778126 | 0.85 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL8630861 | 0.85 | PTGS2 (0.53) | PTGS2PTGS1F10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |