Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628100 | 0.91 | ERBB2 (0.37) | FBP1ERBB2HSP90AA1HSP90AB1PTGES2 | |
| SCHEMBL8630568 | 0.88 | SMN1; SMN2 (0.42) | ERBB2HSP90AA1HSP90AB1PTGES2PTGS1 | |
| SCHEMBL8630354 | 0.88 | MARS1 (0.41) | ERBB2HSP90AA1HSP90AB1PTGES2PTGS1 | |
| SCHEMBL8631576 | 0.87 | MAPT (0.41) | PTGS2MEN1KMT2ACCR2KDM1A | |
| SCHEMBL8634405 | 0.85 | PTGS2 (0.39) | FBP1ERBB2HSP90AA1HSP90AB1PTGES2 | |
| SCHEMBL8631240 | 0.84 | ERBB2 (0.39) | ERBB2HSP90AA1HSP90AB1PTGES2PTGS1 | |
| SCHEMBL8627913 | 0.84 | MAPT (0.40) | ERBB2HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL8628839 | 0.83 | EDNRB (0.41) | PTGS2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8629408 | 0.83 | MAPT (0.41) | PTGS1PTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL8631259 | 0.82 | HSD11B1 (0.39) | FBP1ERBB2HSP90AA1HSP90AB1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |