SCHEMBL8632064

SCHEMBL8632064

Oc1ccc(Oc2ncc(C(F)(F)F)cc2C(F)(F)F)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.53
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C19 P33261 1/20 0.48
HPGD P15428 1/20 0.46
LMNA P02545 3/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
KMT2A Q03164 3/20 0.41
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
ALDH1A1 P00352 1/20 0.40
PKM P14618 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635319 0.89 RAB9A (0.66) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8634738 0.85 RAB9A (0.45) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8635993 0.83 CYP1A2 (0.46) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8634725 0.82 RAB9A (0.50) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8635080 0.78 LMNA (0.42) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8638565 0.77 LMNA (0.41) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8635432 0.77 RAB9A (0.53) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8633984 0.76 RAB9A (0.56) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8637760 0.74 CYP1A2 (0.41) RAB9ACYP1A2CYP3A4CYP2C19HPGD
SCHEMBL8632225 0.73 CYP1A2 (0.40) RAB9ACYP1A2CYP3A4CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed