Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 6/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631464 | 0.92 | PI4KB (0.40) | PI4KBPTGS1PTGS2TP53MDM2 | |
| SCHEMBL8629870 | 0.90 | NPC1 (0.39) | PI4KBPTGS1PTGS2ERN1ACLY | |
| SCHEMBL8634845 | 0.90 | PI4KB (0.38) | PI4KBPTGS1PTGS2ERN1HTR6 | |
| SCHEMBL8632910 | 0.90 | CCR4 (0.42) | CCR4PI4KBPDE4APDE4BPDE4C | |
| SCHEMBL8630396 | 0.87 | PI4KB (0.44) | CCR4PI4KBPDE4APDE4BPDE4C | |
| SCHEMBL8630562 | 0.84 | CCR4 (0.42) | CCR4PI4KBPDE4APDE4BPDE4C | |
| SCHEMBL8635131 | 0.84 | PI4KB (0.43) | CCR4PI4KBPDE4APDE4BPDE4C | |
| SCHEMBL8631394 | 0.84 | AR (0.43) | PTGS2TP53 | |
| SCHEMBL8634518 | 0.83 | PI4KB (0.42) | CCR4PI4KBPDE4APDE4BPDE4C | |
| SCHEMBL8630479 | 0.83 | CCR4 (0.41) | CCR4PI4KBPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |