Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632160 | 0.90 | CCR4 (0.41) | PI4KBERN1PTGS1PTGS2HTR6 | |
| SCHEMBL8631464 | 0.89 | PI4KB (0.40) | PI4KBERN1PTGS1PTGS2PPARA | |
| SCHEMBL8628869 | 0.88 | PTGS2 (0.38) | PI4KBPTGS1PTGS2PPARAEDNRA | |
| SCHEMBL8629870 | 0.87 | NPC1 (0.39) | PI4KBERN1PTGS1PTGS2PPARA | |
| SCHEMBL8635028 | 0.86 | PI4KB (0.40) | PI4KBPTGS1PTGS2EDNRAHTR6 | |
| SCHEMBL8633054 | 0.85 | SMN1; SMN2 (0.41) | AR | |
| SCHEMBL8627805 | 0.83 | PI4KB (0.38) | PI4KBPTGS1PTGS2EDNRAHTR6 | |
| SCHEMBL8631761 | 0.83 | PTGS2 (0.44) | PI4KBPTGS1PTGS2PPARAEDNRA | |
| SCHEMBL8632683 | 0.83 | MEN1 (0.40) | PTGS1PTGS2EDNRAARHTT | |
| SCHEMBL7779840 | 0.83 | PTGS2 (0.47) | PI4KBERN1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |