Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338067 | 0.95 | MAPT (0.53) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL8906504 | 0.92 | L3MBTL1 (0.54) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL8632170 | 0.90 | MAPT (0.64) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL2845644 | 0.88 | MAPT (0.53) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL15294555 | 0.87 | SMN1; SMN2 (0.53) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL22533987 | 0.87 | SMN1; SMN2 (0.55) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL8788713 | 0.85 | APEX1 (0.56) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7338079 | 0.85 | MAPT (0.61) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL8545112 | 0.84 | MEN1 (0.55) | MAPTGAAPKMSMN1; SMN2MAPK1 | |
| SCHEMBL6093891 | 0.83 | SMN1; SMN2 (0.57) | MAPTGAAPKMSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5470867-A | Imidazoles and their salts having antagonistic activity to angiotesin II recetors | ROUSSEL-UCLAF (FR) | 1995-11-28 | — | — | US | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| US-5389634-A | Treating arterial hypertension, relaxing uterus, prevention of post-angioplastic restenosis | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5338756-A | Angiotensin II receptor antagonists | ROUSSEL UCLAF (FR) | 1994-08-16 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0400835-A1 | Substituted benzimidazoles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4880804-A | HYPOTENSIVE AGENTS, CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-11-14 | — | — | US | disclosed |