Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628225 | 0.91 | F10 (0.41) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8632661 | 0.90 | PTGS2 (0.44) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8633655 | 0.88 | F10 (0.47) | F10F2 | |
| SCHEMBL7779948 | 0.84 | PTGS2 (0.49) | CA12CA1CA2CA9MAOB | |
| SCHEMBL8631626 | 0.83 | ALOX5AP (0.43) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7454284 | 0.82 | F10 (0.39) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8629935 | 0.81 | PTGS2 (0.53) | F10 | |
| SCHEMBL8628190 | 0.80 | F10 (0.48) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7772800 | 0.77 | PTGS2 (0.51) | — | |
| SCHEMBL8627787 | 0.74 | F10 (0.38) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |