Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635531 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1TAAR1MAPTMEN1 | |
| SCHEMBL8628774 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL8627989 | 0.87 | PTGS2 (0.48) | PTGS2PTGS1MAPTMEN1POLB | |
| SCHEMBL8629118 | 0.86 | PTGS2 (0.57) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL8629560 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1TP53MAPTMEN1 | |
| SCHEMBL8631162 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1MAPTMEN1POLB | |
| SCHEMBL8631550 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1MAPTMEN1POLB | |
| SCHEMBL8628674 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1MAPTMEN1POLB | |
| SCHEMBL8630859 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1MAPTMEN1POLB | |
| SCHEMBL8630962 | 0.83 | PTGS2 (0.44) | PTGS2TP53MAPTTHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |