Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.40 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947476 | 0.72 | F2 (0.46) | GAAKDM4EMAPTHRH3CYP2C9 | |
| SCHEMBL7961639 | 0.71 | SMN1; SMN2 (0.70) | KDM4EMAPTHRH3CYP2C9CYP2C19 | |
| SCHEMBL8637058 | 0.70 | POLB (0.41) | MAPTHRH3CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL7947472 | 0.69 | SMN1; SMN2 (0.43) | GAAKDM4EMAPTHRH3CYP2C9 | |
| SCHEMBL27651806 | 0.68 | TSHR (0.51) | MAPTALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL18590696 | 0.68 | CHKA (0.67) | GAAKDM4EMAPTHRH3CYP2C9 | |
| SCHEMBL7402715 | 0.68 | PLOD2 (0.53) | GAAKDM4EMAPTPLOD2PLOD3 | |
| SCHEMBL8838002 | 0.67 | HRH3 (0.53) | GAAKDM4EMAPTHRH3CYP2C9 | |
| SCHEMBL8631458 | 0.67 | HRH3 (0.50) | GAAKDM4EMAPTHRH3CYP2C9 | |
| SCHEMBL27463569 | 0.67 | POLB (0.64) | KDM4EMAPTHRH3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |