Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737317 | 0.83 | ALDH1A1 (0.52) | CYP2C9CYP2C19SMN1; SMN2AKR1C3CYP3A4 | |
| SCHEMBL7947472 | 0.83 | SMN1; SMN2 (0.43) | F2F10PRSS1HRH3CYP2C9 | |
| SCHEMBL7961639 | 0.78 | SMN1; SMN2 (0.70) | HRH3CYP2C9CYP2C19SMN1; SMN2AKR1C3 | |
| SCHEMBL28099027 | 0.78 | MAOB (0.52) | CYP2C9CYP2C19SMN1; SMN2AKR1C3CYP3A4 | |
| SCHEMBL4919231 | 0.74 | TDP1 (0.61) | F2CYP2C19SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL3658372 | 0.74 | TDP1 (0.61) | F2CYP2C19SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL7947516 | 0.73 | KDM4E (0.59) | HRH3CYP2C9CYP2C19SMN1; SMN2AKR1C3 | |
| SCHEMBL3506636 | 0.73 | ROCK2 (0.53) | F2F10PRSS1SMN1; SMN2CYP3A4 | |
| SCHEMBL7956784 | 0.72 | HIF1A (0.50) | CYP2C9CYP2C19SMN1; SMN2AKR1C3ALDH1A1 | |
| SCHEMBL7956932 | 0.72 | HIF1A (0.50) | CYP2C9CYP2C19SMN1; SMN2AKR1C3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |