Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947476 | 0.83 | F2 (0.46) | SMN1; SMN2HRH3CYP2C9F2F10 | |
| SCHEMBL7956807 | 0.74 | CA12 (0.46) | SMN1; SMN2CYP2C9CYP2C19CA12CA1 | |
| SCHEMBL8631456 | 0.73 | ALDH1A1 (0.56) | SMN1; SMN2PLA2G1BATG4BCYP2C9CYP2C19 | |
| SCHEMBL7961639 | 0.72 | SMN1; SMN2 (0.70) | SMN1; SMN2HRH3CYP2C9CYP2C19MAPT | |
| SCHEMBL10684394 | 0.72 | NPC1 (0.62) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL7947481 | 0.70 | HRH3 (0.47) | SMN1; SMN2PLA2G1BATG4BHRH3CYP2C9 | |
| SCHEMBL7947608 | 0.69 | MEN1 (0.42) | F2F10PRSS1MAPTKDM4E | |
| SCHEMBL7947475 | 0.69 | KMT2A (0.52) | SMN1; SMN2PLA2G1BATG4BALDH1A1HPGD | |
| SCHEMBL8632345 | 0.69 | GAA (0.42) | SMN1; SMN2HRH3CYP2C9F2F10 | |
| SCHEMBL7958298 | 0.69 | MEN1 (0.41) | SMN1; SMN2CYP2C9CYP2C19CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |