Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632690 | 1.00 | ACE (0.43) | ACEKEAP1 | |
| SCHEMBL8632689 | 1.00 | ACE (0.43) | ACEKEAP1 | |
| SCHEMBL6167536 | 0.82 | ACE (0.36) | ACE | |
| SCHEMBL6167538 | 0.82 | ACE (0.36) | ACE | |
| SCHEMBL9073888 | 0.78 | ACE (0.33) | ACE | |
| SCHEMBL21696767 | 0.77 | ALDH1A1 (0.48) | — | |
| SCHEMBL8634381 | 0.76 | PREP (0.34) | ACEKEAP1 | |
| SCHEMBL8634383 | 0.76 | PREP (0.34) | ACEKEAP1 | |
| SCHEMBL8634379 | 0.76 | PREP (0.34) | ACEKEAP1 | |
| SCHEMBL4936887 | 0.76 | POLB (0.41) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |