Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.34 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634381 | 1.00 | PREP (0.34) | PREPKEAP1NFE2L2PEPDATM | |
| SCHEMBL8634379 | 1.00 | PREP (0.34) | PREPKEAP1NFE2L2PEPDATM | |
| SCHEMBL8632689 | 0.76 | ACE (0.43) | KEAP1ACE | |
| SCHEMBL8632684 | 0.76 | ACE (0.43) | KEAP1ACE | |
| SCHEMBL8632690 | 0.76 | ACE (0.43) | KEAP1ACE | |
| SCHEMBL9409966 | 0.75 | ACE (0.37) | PREPACE | |
| SCHEMBL9409960 | 0.75 | ACE (0.37) | PREPACE | |
| SCHEMBL7321743 | 0.74 | F2 (0.50) | — | |
| SCHEMBL7374895 | 0.73 | CTSK (0.40) | PREP | |
| Formic Acid SCHEMBL28363706 | 0.66 | PEPD (0.46) | PEPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |