Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 10/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633055 | 0.92 | AR (0.39) | PTGS1PTGS2ARGHSRF10 | |
| SCHEMBL7779401 | 0.87 | PTGS2 (0.54) | PTGS1PTGS2AR | |
| SCHEMBL8628074 | 0.85 | F10 (0.40) | PTGS1PTGS2F10F2PRSS1 | |
| SCHEMBL8635053 | 0.84 | PTGS1 (0.44) | PTGS1PTGS2ARDHFRGHSR | |
| SCHEMBL8630521 | 0.84 | PTGS1 (0.45) | PTGS1PTGS2ARDHFRGHSR | |
| SCHEMBL8634846 | 0.84 | PTGS2 (0.41) | PTGS1PTGS2ARF10F2 | |
| SCHEMBL7801339 | 0.83 | PTGS2 (0.44) | PTGS1PTGS2ARGHSR | |
| SCHEMBL8631651 | 0.82 | PTGS2 (0.43) | PTGS1PTGS2ARDHFRGHSR | |
| SCHEMBL8630033 | 0.81 | F10 (0.39) | PTGS1PTGS2F10F2PRSS1 | |
| SCHEMBL8632287 | 0.80 | PTGS2 (0.42) | PTGS1PTGS2ARDHFRGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |