Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 4/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ARF6 | P62330 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635633 | 0.91 | AR (0.36) | PTGS2PTGS1GHSRARHPGD | |
| SCHEMBL8630521 | 0.90 | PTGS1 (0.45) | PTGS2PTGS1GHSRARDHFR | |
| SCHEMBL8635053 | 0.88 | PTGS1 (0.44) | PTGS2PTGS1GHSRARDHFR | |
| SCHEMBL8631651 | 0.87 | PTGS2 (0.43) | PTGS2PTGS1GHSRARDHFR | |
| SCHEMBL7780730 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1AR | |
| SCHEMBL8633221 | 0.85 | PTGS2 (0.38) | PTGS2PTGS1HPGDKDM4ECYP3A4 | |
| SCHEMBL8629873 | 0.83 | PTGS2 (0.41) | PTGS2PTGS1GHSRMAPTNPC1 | |
| SCHEMBL7773332 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1GHSRAR | |
| SCHEMBL8631397 | 0.81 | PTGS2 (0.41) | PTGS2PTGS1ARKDM4ECYP3A4 | |
| SCHEMBL8628708 | 0.81 | PTGDR2 (0.38) | PTGS2PTGS1HPGDKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |