Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | MMP16 | P51512 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364480 | 0.77 | HTR6 (0.55) | HTR6HTR2AHTR2CMMP2MMP9 | |
| SCHEMBL589633 | 0.75 | HTR6 (0.53) | HTR6HTR2AHTR2CMMP2MMP9 | |
| SCHEMBL8632877 | 0.73 | KDM4E (0.44) | HTR6HTR2AHTR2CTSHRHTT | |
| SCHEMBL8637433 | 0.73 | HTR6 (0.44) | HTR6HTR2AHTR2CMMP2MMP9 | |
| SCHEMBL589337 | 0.69 | KMT2A (0.53) | HTR6HTR2AHTR2CMMP2MMP9 | |
| SCHEMBL9252128 | 0.69 | HTR6 (0.42) | HTR6HTR2AHTR2CMMP2MMP9 | |
| SCHEMBL9252114 | 0.69 | MMP2 (0.52) | HTR6MMP2MMP9MMP8MMP12 | |
| SCHEMBL28191444 | 0.68 | KDM4E (0.58) | TSHRHTTKDM4EALDH1A1GAA | |
| SCHEMBL10589344 | 0.67 | HTR6 (0.55) | HTR6MMP2MMP9MMP8MMP12 | |
| SCHEMBL27492085 | 0.67 | HTR6 (0.54) | HTR6HTR2AHTR2CMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | claimed |
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | disclosed |