Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28191444 | 0.81 | KDM4E (0.58) | KDM4EIRAK4CTNNB1MAPTALDH1A1 | |
| SCHEMBL3387938 | 0.76 | CA2 (0.47) | CA1CA2CA5ACA9 | |
| SCHEMBL30269713 | 0.76 | CA2 (0.47) | CA1CA2CA5ACA9 | |
| SCHEMBL2723950 | 0.74 | MYC (0.37) | MAPTALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL8632882 | 0.73 | HTR6 (0.41) | KDM4EHTR2AHTR2CCTNNB1ALDH1A1 | |
| Potassium Ion SCHEMBL11687702 | 0.73 | ELANE (0.35) | HTR6 | |
| Bromide SCHEMBL11100956 | 0.73 | MYC (0.36) | MAPTALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL28440193 | 0.73 | MYC (0.36) | MAPTALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL8997308 | 0.72 | BCAT2 (0.62) | KDM4EHTR2AHTR2CMAPTALDH1A1 | |
| SCHEMBL3641319 | 0.71 | ALDH1A1 (0.45) | KDM4EHTR2AHTR2CMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | claimed |
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | disclosed |