SCHEMBL8633084

SCHEMBL8633084

CC(=O)NN=C(C)c1cccc(Cl)c1

nearest known ligand 0.77

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.77
MEN1 O00255 3/20 0.77
KMT2A Q03164 3/20 0.77
CTSL P07711 1/20 0.68
CYP1A2 P05177 1/20 0.59
CYP3A4 P08684 1/20 0.59
CYP2D6 P10635 1/20 0.59
MAPT P10636 6/20 0.56
GAA P10253 2/20 0.55
KDM4E B2RXH2 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
POLB P06746 2/20 0.53
CASP6 P55212 1/20 0.53
HTT P42858 2/20 0.53
ALDH1A1 P00352 1/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8633080 1.00 SMN1; SMN2 (0.77) SMN1; SMN2MEN1KMT2ACTSLCYP1A2
SCHEMBL943301 0.81 CTSL (1.00) SMN1; SMN2MEN1KMT2ACTSLKDM4E
SCHEMBL8637896 0.80 KMT2A (0.66) SMN1; SMN2MEN1KMT2ACYP1A2MAPT
SCHEMBL8637901 0.80 KMT2A (0.66) SMN1; SMN2MEN1KMT2ACYP1A2MAPT
SCHEMBL27177915 0.79 RAB9A (0.65) SMN1; SMN2MEN1KMT2ACTSLCYP1A2
SCHEMBL30826079 0.79 RAB9A (0.65) SMN1; SMN2MEN1KMT2ACTSLCYP1A2
SCHEMBL27177920 0.79 RAB9A (0.65) SMN1; SMN2MEN1KMT2ACTSLCYP1A2
SCHEMBL8634898 0.79 LMNA (0.74) SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4
SCHEMBL8634895 0.79 LMNA (0.74) SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4
SCHEMBL12186262 0.78 MAPT (0.78) SMN1; SMN2MEN1KMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0704430-B1 N-substituted phenylcarbamic acid derivatives, a process for production thereof, agricultural and horticultural fungicides, intermediates of the derivatives and a process for production thereof NIHON NOHYAKU CO LTD (JP) 1998-07-29 EP disclosed
US-5712399-A N-substituted phenylcarbamic acid derivatives, a process for production thereof, agricultural and horticultural fungicides, intermediates of the derivatives and a process for production thereof NIHON NOHYAKU CO., LTD. (JP) 1998-01-27 US disclosed
US-5650434-A FUNGICIDES NIHON NOHYAKU CO., LTD. (JP) 1997-07-22 US disclosed
EP-0704430-A1 N-substituted phenylcarbamic acid derivatives, a process for production thereof, agricultural and horticultural fungicides, intermediates of the derivatives and a process for production thereof NIHON NOHYAKU CO., LTD. (JP) 1996-04-03 EP disclosed