Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.46 |
| ▸ | EDNRA | P25101 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NAT1 | P18440 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631638 | 0.93 | EDNRB (0.47) | EDNRBEDNRAPTGS2MAPTALDH1A1 | |
| SCHEMBL8627989 | 0.91 | PTGS2 (0.48) | EDNRBEDNRAPTGS2MAPTALDH1A1 | |
| SCHEMBL8633251 | 0.90 | EDNRA (0.41) | EDNRBEDNRAPTGS2MALT1MAPT | |
| SCHEMBL8632637 | 0.88 | EDNRB (0.40) | EDNRBEDNRAPTGS2MAPTALDH1A1 | |
| SCHEMBL8631658 | 0.88 | EDNRB (0.42) | EDNRBEDNRAPTGS2MAPTALDH1A1 | |
| SCHEMBL8631240 | 0.87 | ERBB2 (0.39) | EDNRBEDNRAPTGS2MALT1ERBB2 | |
| SCHEMBL8629982 | 0.86 | EDNRB (0.43) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8630539 | 0.86 | PTGS2 (0.46) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8631938 | 0.85 | ALDH1A1 (0.41) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8631961 | 0.84 | PTGS2 (0.38) | EDNRBEDNRAPTGS2MALT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |