Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PLEC | Q15149 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630170 | 0.93 | CDC7 (0.43) | EDNRBEDNRACDC7PTGS2MAPT | |
| SCHEMBL8631859 | 0.92 | KDM1A (0.41) | EDNRBEDNRAKDM1ACDC7MAPT | |
| SCHEMBL8635531 | 0.92 | PTGS2 (0.50) | EDNRBEDNRACDC7PTGS2MAPT | |
| SCHEMBL8629928 | 0.91 | PTGS2 (0.43) | CDC7PTGS2MAPTMEN1LMNA | |
| SCHEMBL8630539 | 0.89 | PTGS2 (0.46) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8631438 | 0.88 | CYP1A2 (0.46) | PTGS2MAPTKMT2AALDH1A1POLB | |
| SCHEMBL8629382 | 0.88 | ALDH1A1 (0.41) | EDNRBEDNRACDC7PTGS2MEN1 | |
| SCHEMBL8629761 | 0.87 | PTGS2 (0.48) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8631576 | 0.87 | MAPT (0.41) | EDNRBEDNRAKDM1APTGS2MAPT | |
| SCHEMBL8630567 | 0.87 | EDNRB (0.41) | EDNRBEDNRAKDM1APTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |