Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637778 | 0.87 | ROCK2 (0.47) | KMT2AACEGAASMN1; SMN2 | |
| SCHEMBL9871506 | 0.87 | KMT2A (0.59) | PDK2ALOX5KMT2AACENPC1 | |
| SCHEMBL24435015 | 0.87 | KMT2A (0.59) | PDK2ALOX5KMT2AACENPC1 | |
| SCHEMBL10724171 | 0.87 | CNR1 (0.53) | CNR1CNR2PDK2ALOX5KMT2A | |
| SCHEMBL1762519 | 0.87 | KMT2A (0.59) | PDK2ALOX5KMT2AACENPC1 | |
| SCHEMBL13468539 | 0.84 | CNR1 (0.53) | CNR1CNR2PDK2ALOX5KMT2A | |
| SCHEMBL12979193 | 0.83 | CNR1 (0.53) | CNR1CNR2PDK2ALOX5NPC1 | |
| SCHEMBL31562993 | 0.83 | CNR1 (0.53) | CNR1CNR2PDK2ALOX5NPC1 | |
| SCHEMBL3579233 | 0.83 | NPC1 (0.57) | CNR2PDK2KMT2ANPC1RAB9A | |
| SCHEMBL3579235 | 0.83 | NPC1 (0.57) | CNR2PDK2KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |