Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633268 | 0.87 | CNR1 (0.50) | ACEKMT2AGAASMN1; SMN2 | |
| SCHEMBL5568044 | 0.81 | MEN1 (0.45) | ROCK2KLK7ACEMEN1KMT2A | |
| SCHEMBL15473578 | 0.81 | HCRTR1 (0.48) | ROCK2KLK7MEN1KMT2AGAA | |
| SCHEMBL8634319 | 0.80 | GAA (0.45) | GAASMN1; SMN2 | |
| SCHEMBL14905799 | 0.78 | CXCR1 (0.49) | ROCK2KLK7MEN1KMT2ACXCR1 | |
| SCHEMBL10071087 | 0.78 | ACE (0.51) | ACEKLK5 | |
| SCHEMBL5416477 | 0.77 | ROCK2 (0.46) | ROCK2KLK7ACEMEN1KMT2A | |
| SCHEMBL15919528 | 0.76 | ROCK2 (0.55) | ROCK2GAAAVPR2 | |
| SCHEMBL7429992 | 0.76 | ALDH1A1 (0.69) | KLK7MEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL14905797 | 0.76 | CXCR1 (0.47) | ROCK2KLK7MEN1KMT2ACXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |