Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864043 | 0.85 | MET (0.43) | GUSBAHRDYRK3CCNT1CDK9 | |
| SCHEMBL863714 | 0.80 | DYRK3 (0.46) | GUSBDYRK3CCNT1CDK9CDK5 | |
| SCHEMBL863630 | 0.79 | NPC1 (0.52) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16174464 | 0.79 | MAOB (0.43) | L3MBTL1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL863990 | 0.76 | MET (0.42) | L3MBTL1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16009418 | 0.68 | DYRK3 (0.77) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL10094662 | 0.68 | AHR (0.61) | GUSBAHRPIK3CDPIK3CAMTOR | |
| SCHEMBL7091087 | 0.67 | AHR (0.65) | GUSBAHRDYRK1ADYRK2DYRK1B | |
| SCHEMBL856313 | 0.65 | AHR (0.70) | GUSBAHRPIK3CDPIK3CAMTOR | |
| SCHEMBL228554 | 0.64 | AHR (1.00) | GUSBAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865719-B2 | Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865719-B2 | Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865719-B2 | Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-21 | — | — | US | disclosed |
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-03-29 | — | — | US | disclosed |
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-03-29 | — | — | US | disclosed |
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-03-29 | — | — | US | disclosed |
| EP-2406264-A2 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | The Regents of The University of California (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104843-A2 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077816-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS | CHRNA7, CHRNA5, CHRNA1 | GUSB 3021/4885AHR 795/4885DYRK3 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.