Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.33 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | RARG | P13631 | 3/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RARA | P10276 | 5/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8651566 | 0.93 | RARB (0.33) | RARBRXRARARGRXRBRARA | |
| SCHEMBL8660641 | 0.73 | RARB (0.36) | RARBRXRARARGRARA | |
| SCHEMBL8772664 | 0.72 | RARB (0.40) | RARBRXRARARGRARA | |
| SCHEMBL8648772 | 0.71 | RARB (0.36) | RARBRXRARARGRARA | |
| SCHEMBL8772694 | 0.70 | RARG (0.42) | RARBRXRARARGRXRBRARA | |
| SCHEMBL8772752 | 0.70 | RARB (0.36) | RARBRXRARARGRARA | |
| SCHEMBL8772633 | 0.69 | RARB (0.47) | RARBRXRARARGRARA | |
| SCHEMBL8666520 | 0.69 | RARB (0.38) | RARBRARGRARA | |
| SCHEMBL8562392 | 0.68 | RARB (0.42) | RARBRXRARARGRARAMEN1 | |
| SCHEMBL8772662 | 0.68 | RARB (0.42) | RARBRXRARARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825986-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | Allergan (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036609-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN (US) | 1996-11-21 | — | — | WO | disclosed |