Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631118 | 0.90 | MAPT (0.45) | POLBMAPTSMN1; SMN2KMT2APTGS2 | |
| SCHEMBL8629958 | 0.89 | POLB (0.55) | POLBMAPTSMN1; SMN2KMT2AKEAP1 | |
| SCHEMBL8630977 | 0.80 | CA1 (0.49) | POLBMAPTSMN1; SMN2KMT2APTGS2 | |
| SCHEMBL8631115 | 0.75 | KMT2A (0.49) | POLBMAPTSMN1; SMN2KMT2AKEAP1 | |
| SCHEMBL8633853 | 0.75 | MAPT (0.45) | POLBMAPTSMN1; SMN2KMT2APTGS2 | |
| SCHEMBL8628053 | 0.73 | KMT2A (0.45) | MAPTKMT2APTGS2PTGS1 | |
| SCHEMBL595690 | 0.72 | MAPT (1.00) | POLBMAPTSMN1; SMN2KMT2AKEAP1 | |
| SCHEMBL8634435 | 0.72 | MELK (0.58) | PTGS2PTGS1 | |
| SCHEMBL8629371 | 0.72 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL13358957 | 0.72 | CCR1 (0.59) | MAPTSMN1; SMN2PTGS2PTGS1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |