Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632975 | 0.89 | CA1 (0.56) | MAPTPOLBSMN1; SMN2PTGS2CA1 | |
| SCHEMBL8631115 | 0.78 | KMT2A (0.49) | MAPTPOLBSMN1; SMN2PTGS2KMT2A | |
| SCHEMBL2859374 | 0.76 | MAPT (0.52) | MAPTSMN1; SMN2PTGS2CA1CA2 | |
| SCHEMBL2862974 | 0.76 | KEAP1 (0.50) | MAPTPOLBSMN1; SMN2PTGS2KMT2A | |
| SCHEMBL8633742 | 0.75 | POLB (0.55) | MAPTPOLBSMN1; SMN2PTGS2KMT2A | |
| SCHEMBL28189224 | 0.73 | MAPT (0.59) | MAPTPOLBSMN1; SMN2KMT2ATDP1 | |
| SCHEMBL2853595 | 0.72 | LMNA (0.44) | MAPTSMN1; SMN2PTGS2KDM4ELMNA | |
| SCHEMBL2856385 | 0.72 | CCR1 (0.44) | PTGS2CA1CA2CA4LMNA | |
| SCHEMBL8631118 | 0.72 | MAPT (0.45) | MAPTPOLBSMN1; SMN2PTGS2KMT2A | |
| SCHEMBL2855798 | 0.72 | MAPT (0.45) | MAPTSMN1; SMN2PTGS2KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |