Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629371 | 0.81 | PTGS2 (0.52) | PTGS2PTGS1EPHX2CYP2C9 | |
| SCHEMBL8631359 | 0.78 | MELK (0.63) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL18850964 | 0.76 | CA12 (0.70) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL8633742 | 0.73 | POLB (0.55) | KMT2APTGS2PTGS1MAPT | |
| SCHEMBL2859374 | 0.73 | MAPT (0.52) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL8631118 | 0.72 | MAPT (0.45) | KMT2ACA1CA2CA9PTGS2 | |
| SCHEMBL7772921 | 0.72 | CA12 (0.47) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL8631115 | 0.70 | KMT2A (0.49) | KMT2ACA1CA2CA9PTGS2 | |
| SCHEMBL8955949 | 0.68 | PTGS2 (0.77) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL7777513 | 0.68 | CA12 (0.45) | KMT2ACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |