SCHEMBL8633877

SCHEMBL8633877

CC(C)c1ccc(Oc2ccc(OCC=C(Cl)Cl)c(C(C)C)c2)c(C(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 5/20 0.39
RORC P51449 3/20 0.39
HTT P42858 1/20 0.36
P2RX3 P56373 1/20 0.34
P2RX2 Q9UBL9 1/20 0.34
MAPK1 P28482 2/20 0.33
HTR2A P28223 2/20 0.33
SLC6A4 P31645 2/20 0.33
KCNH2 Q12809 2/20 0.33
MAPT P10636 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP2D6 P10635 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA1A P35348 1/20 0.33
FFAR1 O14842 1/20 0.32
BCHE P06276 2/20 0.32
ACHE P22303 2/20 0.32
MEN1 O00255 1/20 0.32
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638273 0.88 AR (0.41) THRBRORCHTTHTR2ASLC6A4
SCHEMBL8636900 0.84 THRB (0.39) THRBRORCHTTHTR2ASLC6A4
SCHEMBL8632642 0.84 LTA4H (0.42) THRBRORCHTTMAPK1MAPT
SCHEMBL8635018 0.84 THRB (0.40) THRBRORCHTTL3MBTL1MEN1
SCHEMBL8635966 0.82 THRB (0.39) THRBRORCHTTP2RX3P2RX2
SCHEMBL8634914 0.82 THRB (0.42) THRBRORCHTTHTR2ASLC6A4
SCHEMBL8635790 0.81 PTGDR (0.37) THRBRORCHTTHTR2ASLC6A4
SCHEMBL8633420 0.81 MAPT (0.42) THRBRORCHTTP2RX3P2RX2
SCHEMBL8635821 0.81 MEN1 (0.46) THRBRORCP2RX3P2RX2MAPK1
SCHEMBL8638487 0.81 THRB (0.40) THRBRORCHTTHTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed