SCHEMBL8638487

SCHEMBL8638487

CC(C)c1cc(Oc2cccc(Cl)c2)ccc1OCC=C(Cl)Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.40
RORC P51449 2/20 0.40
PPARG P37231 2/20 0.39
PPARD Q03181 2/20 0.39
FFAR1 O14842 1/20 0.37
SLC6A4 P31645 2/20 0.36
MAOB P27338 1/20 0.36
AOC3 Q16853 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A3 Q01959 1/20 0.36
HTR2A P28223 1/20 0.36
KCNH2 Q12809 1/20 0.36
RHEB Q15382 1/20 0.35
PTGER4 P35408 1/20 0.35
WDR5 P61964 1/20 0.35
OGG1 O15527 1/20 0.34
HTT P42858 1/20 0.34
LMNA P02545 1/20 0.34
P2RX4 Q99571 1/20 0.34
HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8634095 0.89 THRB (0.40) THRBRORCPPARGPPARDFFAR1
SCHEMBL8635018 0.89 THRB (0.40) THRBRORCMAOBAOC3HTT
SCHEMBL8635821 0.88 MEN1 (0.46) THRBRORCFFAR1
SCHEMBL8635458 0.88 PPARG (0.39) PPARGPPARDFFAR1SLC6A4MAOB
SCHEMBL8637854 0.87 MAOB (0.37) THRBRORCPPARGPPARDSLC6A4
SCHEMBL8636192 0.86 FFAR4 (0.40) THRBRORCPPARDFFAR1
SCHEMBL8632642 0.84 LTA4H (0.42) THRBRORCHTTLMNA
SCHEMBL8634454 0.84 PPARD (0.40) PPARGPPARDFFAR1SLC6A4MAOB
SCHEMBL8635966 0.83 THRB (0.39) THRBRORCHTT
SCHEMBL8633461 0.81 PPARG (0.39) PPARGPPARDFFAR1SLC6A4MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed