Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.65 |
| ▸ | HRH1 | P35367 | 9/20 | 0.65 |
| ▸ | HRH2 | P25021 | 5/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12403566 | 0.89 | DRD2 (0.68) | HRH3HRH1HRH2HTR1ADRD2 | |
| SCHEMBL18590696 | 0.77 | CHKA (0.67) | HRH3HRH1HRH2SIGMAR1 | |
| SCHEMBL7947342 | 0.77 | HRH3 (0.68) | HRH3HRH1HRH2ITGB3ITGA2B | |
| SCHEMBL12261943 | 0.76 | DRD4 (0.77) | HRH3HRH1DRD2HTR2ADRD3 | |
| SCHEMBL12486958 | 0.74 | LTA4H (0.58) | HRH3HRH1 | |
| SCHEMBL2300940 | 0.74 | LTA4H (0.53) | HRH3HRH1 | |
| SCHEMBL8696504 | 0.74 | HRH3 (0.51) | HRH3HRH1HRH2ITGB3ITGA2B | |
| SCHEMBL8634890 | 0.73 | HRH3 (0.50) | HRH3HRH1HRH2ITGB3ITGA2B | |
| SCHEMBL28112415 | 0.73 | CHKA (0.80) | — | |
| SCHEMBL255055 | 0.73 | ESR1 (0.58) | HRH3HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |