Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.50 |
| ▸ | HTR1E | P28566 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634253 | 1.00 | CHRM3 (0.50) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL8638416 | 0.79 | HTR1E (0.48) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL4242909 | 0.75 | ALOX5 (0.49) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL8634916 | 0.75 | CHRM3 (0.47) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL69127 | 0.74 | HTR1E (0.65) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL28622389 | 0.74 | HTR1E (0.65) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL1177709 | 0.73 | HTR1E (0.60) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL1177706 | 0.73 | HTR1E (0.60) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL17846888 | 0.73 | HTR1E (0.47) | CHRM3HTR1ES1PR3LMNAMEN1 | |
| SCHEMBL1565063 | 0.73 | HTR1E (0.47) | CHRM3HTR1ES1PR3LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776964-A | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5521206-A | HYPOTENSIVE AGENTS, TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-28 | — | — | US | disclosed |