Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 8/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696174 | 0.82 | HTR6 (0.43) | PCSK9HTR6HTR1ADRD2HTR2A | |
| SCHEMBL7062997 | 0.82 | CA1 (0.45) | PCSK9HTR6HTR1ADRD2HTR2A | |
| SCHEMBL7678499 | 0.77 | RAPGEF4 (0.56) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL1156091 | 0.73 | ELAVL1 (0.38) | ELAVL1PTGS2PTGS1ALOX5ALDH1A1 | |
| SCHEMBL15155241 | 0.71 | HTR6 (0.39) | HTR6ELAVL1ALDH1A1 | |
| SCHEMBL22104114 | 0.70 | HTR6 (0.38) | HTR6ELAVL1AGTR1ALDH1A1MAPT | |
| SCHEMBL29512049 | 0.70 | HTR6 (0.38) | HTR6AGTR1 | |
| SCHEMBL5776603 | 0.70 | HTR6 (0.38) | HTR6ELAVL1 | |
| SCHEMBL28125877 | 0.69 | POLB (0.41) | HTR6AGTR1ALDH1A1MAPT | |
| Biphenyl SCHEMBL134068 | 0.69 | ALDH1A1 (0.60) | HTR6PTGS2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |